​Many drugs belong to a class of molecules that suffer low aqueous solubility and poor cellular uptake, which leads to a lack of therapeutic efficacy and unwanted side effects. Curcumin (CUR) has many potential therapeutic effects and has been proven to have anti-cancer, anti-inflammatory, and wound-healing abilities. This study aims to develop a CUR nanocarrier to enhance its physiochemical characteristics. First, Mono-6-deoxyl-6-ethylenediamino-γ-cyclodextrin (γCD_EDA) was grafted to a high molecular weight hyaluronic acid (HA) polymer by carbodiimide cross-linking chemistry using various HA:γCD_EDA ratios followed by loading CUR into HA-γCD_EDA conjugate that enable the formation of self-assembled nanoparticles (HA-γCD_EDA NPs and HA-γCD_EDA-CUR NPs).The synthesized HA-γCD_EDA NPs were characterized using ¹H NMR spectroscopy, DLS measurements, thermogravimetry analysis) TGA …​