​This study described a hyaluronic acid (HA) coated niosomes (Nio) encapsulated curcumin (CRM) (CRM‐HA‐Nio) to improve therapeutic properties via targeted delivery. CRM‐HA‐Nio was prepared by thin film hydration method and characterized via dynamic light scattering and transmission electron microscopy. Release assay was performed utilizing dialysis method. Antioxidant, Cell viability, and cellular uptake assays were performed to evaluate the biological activity. CRM‐HA‐Nio has 142.93±39.71 nm size with −20.67±1.10 charge and showed good stability with 93±4.35 % encapsulation efficiency and displayed pH‐independent release pattern. CRM‐HA‐Nio displayed a 2‐fold antioxidant improvement compared to free CRM. CRM‐HA‐Nio showed much better cytotoxic activity on MCF‐7 cell line with IC₅₀ of 1.851±0.45 μM compared to free CRM of IC₅₀ equal to 5.230±0.85 μM, by approximately 3 ​​