​This study investigated the correlation between physical activity and psychological distress in university students. Psychological distress, like depression and anxiety, can have adverse effects on students' academic performance and overall wellbeing. Engaging in physical activity has demonstrated antidepressant and anxiolytic properties that could help alleviate distress. Research on higher education students is limited. A survey was conducted in this study with 250 university students aged 18-25 to assess their physical activity levels and psychological distress symptoms. We assessed physical activity with the International Physical Activity Questionnaire (IPAQ) and measured psychological distress using the Kessler psychological distress scale (K10). IPAQ scores were classified into low, moderate, and high levels of activity. We conducted regression analyses to predict distress levels based on activity levels. The study findings revealed a notable inverse relationship between physical activity and psychological distress. Students who engaged in less activity experienced greater psychological distress compared to those who were moderately or highly active. Engagement in physical activity was a strong predictor of psychological distress levels, even when accounting for factors such as stress and health status. The study emphasises the significance of physical activity in enhancing psychological wellbeing among college students. It is imperative for universities to offer opportunities and programmes that promote physical activity participation. Further research may investigate types and durations of exercise that maximise mental health advantages for students​