Background: Obstructive sleep apnea (OSA) is the most common type of sleep-disordered breathing (SDB) in the general population, affecting women and men up to 9% and 24% respectively. OSA is a multi-systemic disorder that affects various bodily systems, mental health and quality of life. In this study we investigated the prevalence of depression, anxiety, and fatigue among OSA patients.

Methodology: This cross-sectional study was carried out at the respiratory clinic of a teaching and tertiary referral hospital in Jordan, between February 2023 and August 2024. The collected data were categorized into three main groups: Demographics and medical history, anthropometric and clinical parameters and psychological and fatigue screening. The latter was conducted using validated Arabic versions of hospital Anxiety and Depression Scale (HADS) and the Fatigue Severity Scale (FSS). 

Results: A total of 94 OSA patients were included in the study with an average age of 51.43 years (±12.7). Their average BMI was 37.31 (±6.84 kg/m²). Females constituted 57.4% of the study group. Additionally, hypertension (57.4%) and diabetes mellitus (40.4%) were being the most common Co-morbidities identified. Severe OSA was identified in 72.3% of cohort, while 15.9% had moderate OSA. The prevalence of anxiety and depression was 54.3% and 56.4%, respectively. 

Conclusion: This study underscores the high prevalence of fatigue, depression, and anxiety in patients with OSA. This highlights the importance of mental health aspects among patients with OSA. Future research should employ randomized controlled trials with larger, more diverse populations and standardized, validated assessment tools to inform future multidisciplinary management strategies in similar healthcare settings.