Despite the continuous efforts to synthesize new antibacterial compounds , most are still at a pre-clinical stage and shortage of new antibiotics is anticipated. Therefore, it is necessary to make the best use of currently available agents. Amoxicillin is the most commonly used antibiotic for treatment of orofacial infections as well as prophylaxis of endocarditis in children and adults. Understanding the pharma-cokinetics of drugs helps to shape the appropriate clinical practices and provide guidance for clinicians. Clinical guidelines for prescribing have been established and explained in several resources. However the pharmacokinetic basis for prescribing is probably an underestimated and less tackled area among clinicians. Therefore, we critically reviewed the literature to describe pharmacokinetics of oral amoxicillin in orofacial infections to provide better understanding of the guidelines and aid evidence-based prescribing practices.​