The Nanomedicine and Drug Delivery Science Research Group
**Current members:
1. Dana Haj Ali, Phd candidate
Department of Pharmaceutical Sciences, School of Pharmacy, University of Jordan.
Thesis title: Aptamer-Functionalized Dexamethasone-Loaded Polymeric-Micelle Nanoparticles for Targeting Cancer.
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2. Bushra Sabbah, PhD Candidate.
Department of Biological Sciences, School of Science, University of Jordan.
Thesis title: In Vitro Investigation of Anticancer Effect of Tin/Silver Nanoparticles Against Breast Cancer Cells.
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3. Aya Khalaf, PhD Candidate.
Department of Chemistry, School of Science, University of Jordan.
Thesis title: Developing New Protamine-Functionalized Phospholipids Conjugates for Promising Therapeutic Applications.
4. Majdoleen Rababaah, PhD Candidate.
Thesis title: Drug Delivery System Using Functionalized and Modified Cucurbiturils Encapsulated in Liposomes.
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5. Hadeel Abu Saifan, MSC student
Department of Pathology, microbiology, and forensic medicine, School of Medicine, University of Jordan.
Thesis title: In Vitro Selection of DNA Aptamers for Tumor Biomarkers.
6. Noor Adayleh, MSC student
Department of Pharmaceutics and Pharmaceutical Technology, School of Pharmacy, University of Jordan.
Thesis title: Loading of Anti-inflammatory Drug Into Albumin Based Nanoparticles.
7. Yousef Ijjeh, PharmD., Research Assistant.
MSc in Biomedical Engineering from Université Paris Descartes
Cell Therapy Center, University of Jordan.
8. Nirmeen Mansour, Research Assistant
MSc in Biotechnology and Genetic Engineering, JUST
9. Nowar Alsarayreh, Research Assistant
MSc in Biology, University of Jordan.
10. Helen Al-zain, Lab Technician,
Cell Therapy Center, University of Jordan, Jordan.
**Past students:
I. MSc students
1. Student name: Amer Amer. Graduated (Dec/2018) Supervisors: Prof. Yaser bustanji, Dr.Walhan Alshaer (Co-supervisor). Department of Biopharmaceutics and Clinical Pharmacy/Faculty of pharmacy/The University of Jordan. Thesis title “Antitumor activity of nanoliposomes encapsulating Echinomycin."Pubilcation link: https://doi.org/10.1039/C9RA05636J
2. Student name: Arwa Alkaraki. Graduated (Apr/2019) Supervisor: Dr.Walhan Alshaer (main supervisor). Department of Pharmacology /Faculty of Medicine/The University of Jordan. Thesis title “Enhancing the therapeutic efficacy and potency of chemotherapeutics by silencing of genes involved in multidrug resistance mechanism".Pubilcation link: https://doi.org/10.1007/s12282-020-01098-9
3. Student name: Student name: Abdulfattah Al-Kadash. Graduated (Dec/2019) Supervisor: Dr.Walhan Alshaer (main supervisor). Department of Pharmacology /Faculty of Medicine/The University of Jordan. Thesis title “Anti-Tumor Activity of Single and Combinatorial siRNA Through Silencing Oncogenes Involved in Pancreatic Cancer: Therapeutic Approach".Pubilcation link: https://doi.org/10.2144/fsoa-2023-0145
4. Student name: Student name: Hafsa Al-Azzawi. Graduated (Dec/2019) Supervisors: Dr. Walhan Alshaer, Prof. Abdalla Saleh Awidi and Dr. Belal Azab. Department of Pathology and Microbiology and Forensic Medicine/Faculty of Medicine/The University of Jordan. Thesis title “Developing nanoparticles for intracellular delivery of aptamers into cells".Pubilcation link: https://doi.org/10.1016/j.jddst.2022.103169
5. Student name: Ahmed Sadaalhanjori. Graduated (Feb/2020) Supervisors: Prf. Malek Zihlif, Dr. Walhan Alshaer (Co-Supervisor). Department of Pharmacology/Faculty of Medicine/The University of Jordan. Thesis title “Studying Antitumor Effects of siRNA Gene Silencing of Some Metabolic Genes in Pancreatic Cancer".Pubilcation link: https://doi.org/10.2174/1874467213666201012162250
6. Student name: Hiba Tarek. graduated (December/2020) Supervisors: Prf. Talal Aburjai, Dr. Walhan Alshaer (Co-Supervisor). Department of Pharmaceutical sciences/Faculty of Pharmacy/The University of Jordan. Thesis title “Encapsulation of Capsaicin-in-cyclodextrin inclusion complexes into liposomes: in vitro anti-inflammatory potential against cancer cells"Pubilcation link: https://doi.org/10.1515/znc-2021-0018
7. Student name: Mohammad Ismail. Graduated (May/2021) Supervisors: Dr. Walhan Alshaer, and Dr. Belal Azab. Department of Pathology and Microbiology and Forensic Medicine/Faculty of Medicine/The University of Jordan. Thesis title “Development Of Lipopolyplex-Based Nanocarriers For Targeted Gene Delivery Purposes".
8. Student name: EzAldeen Alessawi. Graduated (August/2021) Supervisors: Dr. Walhan Alshaer, and Dr. Belal Azab. Department of Department of Pathology and Microbiology and Forensic Medicine/Faculty of Medicine/The University of Jordan. Thesis title “Targeted Delivery Of Adenosine Triphosohate Atp- Aptamer For Controlled Release Of Doxorubicin Into Cancer Cells Using As1411 Aptamer".Pubilcation link: https://doi.org/10.3390/ijms222312940
9. Student name: Sumaay Naser. Graduated (December/2021); Supervisors: Dr. Walhan Alshaer, and Dr. Fadwa Odeh. Department of Chemistry/Faculty of Science/The University of Jordan. Thesis title “Effect of Cucurbiturils on Phosphatidylcholine Lipid Bilayer: A Study of the Stability and Interactions with Liposomes".
10. Student name: Tasneem Sartawee. Graduated (December/2021); Supervisors: Dr.Walhan Alshaer (main-Supervisor). Department of Biology/Faculty of Science/the University of Jordan. Thesis title “In Vitro Cellular Interaction Of Drug-Loaded Liposomes with 2d And 3d Cell Culture of U87-Mg Cell Line".
11. Student name: Aseel Mohammad Al-Diqs. Graduated (Jan/2022) Supervisors: Dr. Walhan Alshaer, and Prof. Dr. Mohammed Al-Tanani. Department of Pharmaceutical Science/Faculty Of Pharmacy/Al-Ahliyya Amman University.Thesis title “Developing a Nanodelivery System of Pimozide as an Effective Anticancer Agent: PhysicochemicalCharacterization and Biological activity."
12. Student name: Dalya Abdulghafoor Saidi. Graduated (Jan/2022). Supervisors: Dr. Walhan Alshaer, and Dr. Marya Obeidat. . Department of Medical Laboratory Sciences/Faculty of Applied Medical Sciences/ Jordan University of Science and Technology. Thesis title “Investigating the Efficacy of Lyophilized AS1411- Gold Nanosphere Conjugated Aptamer in Breast Cancer".Publication link: https://doi.org/10.1016/j.heliyon.2024.e30743
13. Student name: Toqa Ayman Almaitah. Graduated (Aug /2022). Supervisors: Dr. Walhan Alshaer, and Dr. Khawla Al-Hamaideh. Department of Medical Laboratory Sciences/Faculty of Applied Medical Sciences/ Al-Balqa' Applied University. Thesis title “In Vitro Study of the Inflammatory Potential of Nanoliposomes in the THP-1 Macrophage Model".
14. Student name: Tasneem Alaa Ryal. Graduated (May/2023). Supervisors: Dr. Hatem Alkhateeb, and Dr. Walhan ALSHAER. Department of Pharmaceutical Sciences/Faculty of Pharmacy/The University of Jordan. Thesis title “Evaluation of tissue permeation and cellular uptake of vitamin C solid formulated in oil in water nano-emulsions"
15. Student name: Basma Ateeq Abu msafer. Graduated (Jun/2023) Supervisors: Dr. Walhan Alshaer, and Prof. Manal A. Abbas. Department of Medical Laboratory Sciences/Faculty Of Pharmacy/Al-Ahliyya Amman University.Thesis title “Effect of Palbociclib on expression of platelets activation marker "CD62P" after co-culture with breast cancer cells."
16. Student name: Shrouq Fajer Zaki Twal. Graduated (August/2023) Supervisors: and Prof. Mayyas Al-Remawi and Dr. Walhan Alshaer. Department of Pharmaceutical Sciences /Faculty Of Pharmacy/Petra University.Thesis title “Novel Soluplus and Chitosan dual stimuli-responsive nanoparticles for targeting cancer cells".Pulication link: http://dx.doi.org/10.1039/d3ra08074a
17. Student name: Mais Emad Moh'd Said. Graduated (August/2023) Supervisors: and Dr. Dua'a Abu Arqoub and Dr. Walhan Alshaer. Department of Pharmaceutical Sciences /Faculty Of Pharmacy/Petra University.Thesis title “The Impact of Hydroxyapatite Nanoparticles on the cellular processes of Stem Cells derived from dental tissue sources".
18. Student name: Nowar Mousa Salem Al Sarayrah. Graduated (August/2023); Supervisors: Dr.Walhan Alshaer and Dr. Sharif Abedalghani. Department of Biology/Faculty of Science/The University of Jordan. Thesis title “A Comaparative in Vitro Study of the Efficacy of Gemcitabine Nanocrystals and Niosomes as an Alternative Drug Delivery Method for Tumor Targeting".Publication link: http://dx.doi.org/10.1016/j.jddst.2024.105617
19. Student name: Shiraz Odeh AlAsasfeh. Graduated (December/2023); Supervisors: Dr.Walhan Alshaer and Dr. Shtawi Abdallah. Department of Biology/Faculty of Science/The University of Jordan. Thesis title: Potential Effect of Botulinum Toxin A on Isolated Aortic Reactivity and its Influence on MCF-7 Breast Cancer Cell Line Resistance to Doxorubicin.
20. Student name: Dana Daqqa. Graduated (May/2024) Supervisor: Dr.Walhan Alshaer and Prof. Malek Zihlif. Department of Pharmacology /Faculty of Medicine/The University of Jordan. Thesis title: “The enhancement effect of metformin when combined with chromomycin a3-loaded nanoliposomes on different types of cancer cell lines ”.
21. Student name: Shatha Alramahi. Graduated (May/2024) Supervisor: Dr.Walhan Alshaer and Prof. Malek Zihlif. Department of Pharmacology /Faculty of Medicine/The University of Jordan. Thesis title “Metformin enhances the anticancer effect of echinomycin-loaded nanoliposomes on different types of cancer cell lines upon simultaneous exposure.”
22. Student name: Taima K. Al-Shboul. Graduated (August/2024). Supervisor: Dr.Walhan Alshaer and D. Manar Zraikat. Department of Pharmacology /Faculty of Medicine/The University of Jordan. Thesis title “Modulating a Smart Delivery System for Metformin Targeting Glioblastoma u87 – cell Line”.
II. PhD students
Student name: Ala'a Shraim. Graduated (Mar/2018) Supervisors: Prf. Abdelrahim A. Hunaiti, Prf. Abdullah S. Awidi, Dr.Walhan Alshaer (Co-Supervisor). Department of Biology/Faculty of Science/The University of Jordan. Thesis title “Developing and Characterization of Aptamers Targeting the Kinase Domain of Group III Receptor Tyrosine Kinases".Publication link: https://doi.org/10.1021/acs.jmedchem.9b00868
Student name: Hamdi Alnsairat. Graduated (Dec/2019) Supervisors: Prf. Abeer Fayez Albawab, Prf. Fadwa Mohammed Odeh, Dr.Walhan Alshaer (Co-Supervisor). Department of Chemistry/Faculty of Science/The University of Jordan. Thesis title “Remote Drug Loading and Ligand-Functionalization of Liposomes for Targeted Drug Delivery into Cancer Cells".Publication link: https://doi.org/10.1039/D0RA07325C
Student name: Zainab M. Lafi. Graduated (Apr/2020) Supervisors: Prf. Yasser Bustanji, Dr. Walhan Alshaer (Co-Supervisor). Department of Pharmaceutical sciences/Faculty of Pharmacy/The University of Jordan. Thesis title “Formulation and Functionalization of Aptamer-Guided pH-Sensitive Liposomes for Targeted Drug Delivery of Echinomycin-Cyclodextrin Complex into Cancer Cells".Publication link: https://doi.org/10.1039/D1RA05138E
Student name: Lobna Gharaibeh. Graduated (Apr/2020) Supervisors: Prf. Yasser Bustanji, Walhan Alshaer (Co-Supervisor). Department of Pharmaceutical sciences/Faculty of Pharmacy/The University of Jordan. Thesis title “Aptamer-Guided Liposomes for Selective Delivery of siRNA Combination into Cancer Cells".Publication link: https://doi.org/10.1016/j.jddst.2021.102733
Student name: Ali Al-Samydai Graduated (July/2020) Supervisors: Supervisors: Prf. Abeer Fayez Albawab, Prf. Fadwa Mohammed Odeh, and Dr.Walhan Alshaer (Co-Supervisor). Department of Pharmaceutical sciences/Faculty of Pharmacy/The University of Jordan. Anticancer Activity of Capsicum annuum: Capsaicin Loaded Nano-Liposomes model.Publication link: https://www.mdpi.com/2072-6643/14/23/5170#
Student name: Fedaa Al-Adaileh. Graduated (May/2022). Supervisors: Prof. Talal Aburjai, Dr.Walhan Alshaer (Co-Supervisor). Department of Chemistry/Faculty of Science/The University of Jordan. Thesis title “Crosslinking of water-soluble cyclodextrin with hyaluronic acid for targeted drug delivery".Publication link: https://doi.org/10.1016/j.jddst.2023.104886
Student name: Usamah Sayed. Graduated (Jan/2023) Supervisors: Dr.Walhan Alshaer (Supervisor), and Prf. Malek Zihlif. Department of Chemistry/Faculty of Science/The University of Jordan. Thesis title “Hyaluronic Acid-Coated Chromomycin A3-Loaded Nanoliposomes For Selective Targeting Of Cd44-Expressing Tumor Cells".
Student name: Mohammad Ahmed Issa Alhatamleh. Graduated (May/2023)Synthesis, Supervisors Dr. Rohimah Mohamud and Dr.Walhan Alshaer (field advisor). Department of Immunology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia. Thesis title “Characterization and Evaluation of Immunomodulatory, Anticancer, Antibacterial and Wound Healing Activities of Alginate Nanoparticles Loaded with Heterotrigona itama Honey".Publication link: https://doi.org/10.3389/fmolb.2022.865833