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Mechanisms of pain processing and analgesia

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Mechanisms of pain processing and analgesia

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Featured Publications

Cisplatin Provokes Peripheral Nociception and Neuronal Features of Therapy-Induced Senescence and Calcium Dysregulation in Rats

Authors: Tareq Saleh, Randa Naffa, Noor A Barakat, Mohammad A Ismail, Moureq R Alotaibi, M Alsalem 2024

Journal: Neurotoxicity Research

Doi: https://doi.org/10.1007/s12640-024-00690-7

Targeting therapy-induced senescence as a novel strategy to combat chemotherapy-induced peripheral neuropathy

Authors: M Alsalem, Amr Ellaithy, Sarah Bloukh, Mansour Haddad, Tareq Saleh 2024

Journal: Supportive Care in Cancer

Doi: https://doi.org/10.1007/s00520-023-08287-0

The neuroprotective effect of human primary astrocytes in multiple sclerosis: In vitro model

Authors: Amer Imraish,Tuqa Abu Thiab,Mohammad Alsalem ,Saeed Dahbour,Hiba khleif,Basha’er Abu-Irmaileh,Raneen Qasem,Khalid El-Salem2024

Journal: Plos one

Doi: https://doi.org/10.1371/journal.pone.0300203

Adenosine Receptors as Potential Therapeutic Analgesic Targets

Authors: Mansour Haddad, Federica Cherchi, M Alsalem, Yousef M Al-Saraireh, Saba Madae’en2023

Journal: International Journal of Molecular Sciences

Doi: https://doi.org/10.3390/ijms241713160

Interaction of the synthetic cannabinoid WIN55212 with tramadol on nociceptive thresholds and core body temperature in a chemotherapy-induced peripheral neuropathy pain model

Authors: Mansour Haddad, M Alsalem, Tareq Saleh, Sahar M Jaffal, Noor A Barakat, Khalid El-Salem 2023

Journal: NeuroReport

Doi: https://doi.org/10.1097/wnr.0000000000001910

Role of bradykinin and prostaglandin EP4 receptors in regulating TRPV1 channel sensitization in rat dorsal root ganglion neurons

Authors: Sara A Aldossary, M Alsalem, Blair D Grubb2023

Journal: Basic & Clinical Pharmacology & Toxicology

Doi: https://doi.org/10.1111/bcpt.13967

The role of adenosine receptor ligands on inflammatory pain: possible modulation of TRPV1 receptor function

Authors: Mansour Haddad, M Alsalem, Sara A Aldossary, Heba Kalbouneh, Sahar M Jaffal, Qusai Alshawabkeh, Sa’ed Al Hayek, Omar Abdelhai, Noor A Barakat, Khalid El-Salem 2023

Journal: Inflammopharmacology

Doi: https://doi.org/10.1007/s10787-022-01127-3

Effect of Arbutus andrachne L. methanolic leaf extract on TRPV1 function: Experimental and molecular docking studies

Authors: Sahar Jaffal, Sawsan Oran, M Alsalem2022

Journal: Journal of Applied Pharmaceutical Science

Doi: https://doi.org/10.7324/JAPS.2022.121007

Preclinical comparison of antinociceptive effects between ibuprofen, diclofenac, naproxen, and acetaminophen on acid-stimulated body stretching and acid-depressed feeding behaviors in rats

Authors: Altarifi, Ahmad A; Younis, Bassel A; Nuseir, Khawla Q; Al-Mousa, Arwa A; Qaoud, Ahmad K; Alsalem, Mohammad; Neubert, John2022

Journal: Behavioural Pharmacology

Doi: https://doi.org/10.1097/FBP.0000000000000704

Anti-inflammatory and antipyretic potential of Arbutus andrachne L. methanolic leaf extract in rats

Authors: SM Jaffal, SA Oran, M Alsalem 2021

Journal: Asian Pacific Journal of Tropical Biomedicine

Doi: https://doi.org/10.4103/2221-1691.328056

Analgesic Effects and Impairment in Locomotor Activity Induced by Cannabinoid/Opioid Combinations in Rat Models of Chronic Pain

Authors: Mohammad Alsalem, Ahmad Altarifi, Mansour Haddad, Belal Azab, Heba Kalbouneh, Amer Imraish, Tareq Saleh, Khalid El-Salem2020

Journal: Brain sciences

Doi: https://doi.org/10.3390/brainsci10080523

Preclinical assessment of tramadol abuse potential: Effects of acute and repeated tramadol on intracranial self-stimulation in rats

Authors: Ahmad A Altarifi, M. Moerke, M. Alsalem, S. Negus2020

Journal: Journal of Psychopharmacology

Doi: https://doi.org/10.1177/0269881120944153

The desensitization of the transient receptor potential vanilloid 1 by nonpungent agonists and its resensitization by bradykinin

Authors: Mohammad Alsalem, Sara A Aldossary, Mansour Haddad, Ahmad Altarifi, Heba Kalbouneh, Belal Azab, Ayman G Mustafa, Sahar M Jaffal, Khalid El-Salem2020

Journal: Neuroreport

Doi: https://doi.org/10.1097/WNR.0000000000001485

Antinociceptive and Abuse Potential Effects of Cannabinoid/Opioid Combinations in a Chronic Pain Model in Rats

Authors: Mohammad Alsalem, Ahmad Altarifi, Mansour Haddad, Sara A Aldossary, Heba Kalbouneh, Nour Aldaoud, Tareq Saleh, Khalid El-Salem 2019

Journal: Brain sciences

Doi: https://doi.org/10.3390/brainsci9110328

Effects of combined swimming exercise and non‑steroidal anti‑inflammatory drugs on inflammatory nociception in rats.

Authors: AA Altarifi, Z Kalha, SF Kana'an, MA Alfaqih, M Alsalem 2019

Journal: Experimental and therapeutic medicine

Doi: https://doi.org/10.3892/etm.2019.7413

Effects of Dual Peroxisome Proliferator-Activated Receptors and Activation in Two Rat Models of Neuropathic Pain.

Authors: Mohammad Alsalem, Mansour Haddad, Sara A Aldossary, Heba Kalbouneh, Belal Azab, Aala Dweik, Amer Imraish, Khalid El-Salem 2019

Journal: PPAR research

Doi: https://doi.org/10.1155/2019/2630232

Effects of intraplantar administration of Complete Freund’s Adjuvant (CFA) on rotarod performance in mice

Authors: A Altarifi, M Alsalem, A Mustafa 2019

Journal: Scandinavian journal of pain

Doi: https://doi.org/10.1515/sjpain-2018-0358

Role of cannabinoid receptor 1 and the peroxisome proliferator-activated receptor α in mediating anti-nociceptive effects of synthetic cannabinoids and a cannabinoid-like compound

Authors: M Alsalem, M Haddad, S A Aldossary, H Kalbouneh, A Altarifi, SM Jaffal, MA Abbas, N Aldaoud, K El-Salem2019

Journal: Inflammopharmacology

Doi: https://doi.org/10.1007/s10787-019-00584-7

The role of transient receptor potential vanilloid receptor 1 and peroxisome proliferator-activated receptors-α in mediating the antinociceptive effects of palmitoylethanolamine in rats

Authors: SA. Aldossary, M Alsalem, H Kalbouneh, M Haddad, B Azab, O Al-shboul, A G. Mustafa, S Obiedat and K El-Salem2019

Journal: NeuroReport

Doi: https://doi.org/10.1097/WNR.0000000000001161

Anti-nociceptive and desensitizing effects of olvanil on capsaicin-induced thermal hyperalgesia in the rat

Authors: Alsalem, M, Millns, P, Altarifi, A, El-Salem, K, Chapman, V, Kendall, D2016

Journal: BMC Pharmacology and Toxicology

Doi: https://doi.org/10.1186/s40360-016-0074-9

The contribution of the endogenous TRPV1 ligands 9-HODE and 13-HODE to nociceptive processing and their role in peripheral inflammatory pain mechanisms

Authors: Alsalem, M, Wong, A, Millns, PJ, Arya, PH, Chan, M, Bennett, A, Barrett, D, Chapman, V, Kendall 2013

Journal: Br J Pharmacol

Doi: https://doi.org/10.1111/bph.12092

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