​Vitamin E has been previously studied for its skin protective properties. However, due to its lack of stability, the pro-vitamin E, tocopherol phosphate (TP) proposes a reliable alternative for use in therapeutic formulations. In this work, the wound healing properties of TP were studied in vitro on Human Dermal Fibroblasts (HDF) by scratch test method and in vivo for the first time on mouse excisional wound model. The TP was studied in two forms; in its free form (TP) and liposomal formulation (TPLP). The HDF scratch assay showed a significant increase in the wound closure percentage when treated with 0.1 µM TP-loaded liposome compared to the negative control. In the in vivo studies, both TP and TPLP were added to cold cream base in a ratio of 1 to 4. Both TP and TPLP showed comparable​ wound healing rate to the positive control (MEBO), all showed higher wound closure percentage at day 14 compared to the negative control. These findings propose an excellent therapeutic effect of TP liposome in wound management if applied topically in skin.

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