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Innovation in Oral and Parenteral Drug Delivery Technologies

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Featured Publications

A comparative study of cationic lipid-enriched LNPs for mRNA vaccine delivery

Authors: Burcu Binici, Zahra Rattray, Yvonne Perrie*2025

Journal: International Journal of Pharmaceutics

Doi: https://doi.org/10.1016/j.ijpharm.2025.125941

Curcumin-loaded Niosomes Prepared by Microfluidic Mixing; Characterization and Cytotoxicity Evaluation

Authors: Saif Aldeen Jaber, Mohamed Saadh, Qamar Abuhassan & Mohammad A. Obeid2025

Journal: Journal of Pharmaceutical Innovation

Doi: https://doi.org/10.1007/s12247-025-10003-w

Design and synthesis of chromene-triazole hybrids via recyclable magnetic nanocatalyst: Potent dual-acting anticancer agents targeting apoptotic and microtubule dynamics.

Authors: Mohamed J. Saadh a, Zainab Nizar Jawad b c , Shahad Mohammed Dhiaa Younis d , Wathiq Kh. Mohammed e , Muntadher Kadhum Sultan f , Jasur Rizaev g , Usama S. Altimari h, Mokhtar Jasim Naser i , Murtadha Laftah Shaghnab j , Hasanain Khaleel Shareef k2025

Journal: Journal of Molecular Structure

Doi: https://doi.org/10.1016/j.molstruc.2025.142093

Drug delivery systems incorporating bile salts: advancements since the conception of bilosomes

Authors: Mohammad A. Obeid,Marta Ruano-Aldea,Reinaldo Acevedo,Virgil Schjins,Manal M. Alsaadi &Valerie A. Ferro2025

Journal: Therapeutic Delivery

Doi: https://doi.org/10.1080/20415990.2025.2469488

Engineered Extracellular Vesicles for Targeted Paclitaxel Delivery in Cancer Therapy: Advances, Challenges, and Prospects.

Authors: Mohamed J. Saadh, Hanan Hassan Ahmed, Radhwan Abdul Kareem, Ashishkumar Kyada, H. Malathi, Deepak Nathiya, Deepak Bhanot, Waam Mohammed Taher, Mariem Alwan, Mahmood Jasem Jawad & Atheer Khdyair Hamad 2025

Journal: Cellular and Molecular Bioengineering

Doi: https://doi.org/10.1007/s12195-025-00858-x

Evaluating the impact of bioinspired counterion inclusion on silk nanoparticle physicochemical attributes and physical stability

Authors: Napaporn Roamcharern, Panida Punnabhum, F. Philipp Seib, Zahra Rattray*2025

Journal: Nanoscale Advances

Doi: https://doi.org/10.1039/D5NA00365B

In Silico design and molecular dynamics analysis of imidazole derivatives as selective cyclooxygenase-2 inhibitors.

Authors: Mohamed J. Saadh a, Hanan Hassan Ahmed b , Radhwan Abdul Kareem c , Vicky Jain d , Suhas Ballal e , Abhayveer Singh f , Girish Chandra Sharma g , Anita Devi h , Abdulaziz Nasirov i , Hayder Naji Sameer j , Ahmed Yaseen k , Zainab H. Athab l , 2025

Journal: Computational Biology and Chemistry

Doi: https://doi.org/10.1007/s12195-025-00858-x

Nanobodies: a new frontier in influenza virus neutralization.

Authors: Mohamed J. Saadh, Waleed K. Abdulsahib, Ashok Kumar Bishoyi, Suhas Ballal, Abhayveer Singh, Suman Saini, Khasankhodja Abidov, Kamal Kant Joshi, Munther Kadheem, Manizhe Jozpanahi & Mohammad Darvishi 2025

Journal: Folia Microbiologica

Doi: https://doi.org/10.1007/s12223-025-01303-2

Optimizing silk nanoparticle assembly with potassium ions: effects on physicochemical properties and encapsulation efficiency

Authors: Napaporn Roamcharern, Daniel J. Brady, John A. Parkinson, Zahra Rattray, F. Philipp Seib*2025

Journal: Applied bio materials

Doi: https://doi.org/10.1021/acsabm.5c00598

Quantifying antibody binding: techniques and therapeutic implications

Authors: James Lodge, Lewis Kajtar, Rachel Duxbury, David Hall, Glenn A. Burley, Joanna Cordy, James W.T. Yates, Zahra Rattray*2025

Journal: mAbs

Doi: https://doi.org/10.1080/19420862.2025.2459795

A novel simulated media system for in vitro evaluation of bioequivalent intestinal drug solubility

Authors: Qamar Abuhassan a , c , Maria Inˆ es Silva Hannah K. Batchelor a , Kate Pyper b a , Rana Abu-Rajab Tamimi , Gavin W. Halbert a a , *2024

Journal: European Journal of Pharmaceutics and Biopharmaceutics

Doi: https://doi.org/10.1016/j.ejpb.2024.114302

Iridium (Ir) decorated silicon Carbide (SiC) nanosheet as a promising sensitive material for detection of γ-Hydroxybutyric acid drug based on the DFT approach.

Authors: Mohamed J. Saadh,Yathrib Ajaj,Mohammed Ahmed Mustafa,Nada Othman Kattab,Sameh M. Osman,Hijaz Ahmad,Salim B. Alsaadi,Ahmed Read Al-Tameemi &Ahmed Elawady2024

Journal: Molecular Physics

Doi: https://doi.org/10.1080/00268976.2024.2356754

Preparation and characterizations of chitosan–octanoate nanoparticles for efficient delivery of curcumin into prostate cancer cells

Authors: Ahmad Bani-Jaber, Safaa Taha, Rana Abu-Dahab, Samaa Abdullah, Dina El-Sabawi, Alaa A. Al-Masud, Alhassan H. Aodah & Abeer A. Altamimi 2024

Journal: 3 Biotech

Doi: https://doi.org/10.1007/s13205-024-04157-6

Current state of, prospects for, and obstacles to mRNA vaccine development

Authors: Alaa A. A. Aljabali, Rasha M. Bashatwah, Mohammad A. Obeid, Vijay Mishra, Yachana Mishra, Ángel Serrano-Aroca, Kenneth Lundstrom, Murtaza M. Tambuwala2023

Journal: Drug Discovery Today

Doi: https://doi.org/10.1016/j.drudis.2022.103458

Formulation and evaluation of nanosized hippadine-loaded niosome: Extraction and isolation, physicochemical properties, and in vitro cytotoxicity against human ovarian and skin cancer cell lines

Authors: Mohammad A. Obeid a 1 , Comfort A. Ogah b 1 , Celina O. Ogah c , Olusegun S. Ajala c , Marta Ruano Aldea d , Alexander I. Gray d, John I. Igoli e, Valerie A. Ferro d2023

Journal: Journal of Drug Delivery Science and Technology

Doi: https://doi.org/10.1016/j.jddst.2023.104766

Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation.

Authors: Mohammad Chehelgerdi, Matin Chehelgerdi, Omer Qutaiba B. Allela, Renzon Daniel Cosme Pecho, Narayanan Jayasankar, Devendra Pratap Rao, Tamilanban Thamaraikani, Manimaran Vasanthan, Patrik Viktor, Natrayan Lakshmaiya, Mohamed J. Saadh, Ayesha Amajd, Mabrou2023

Journal: Molecular Cancer

Doi: https://doi.org/10.1186/s12943-023-01865-0

Structural Insights into Magnetic Clusters Grown Inside Virus Capsids

Authors: M. Jaafar, Alaa A. A. Aljabali, I. Berlanga, R. Mas-Ballesté, P. Saxena, S. Warren, G. P. Lomonossoff, D. J. Evans, P. J. de Pablo2023

Journal: ACS Applied Materials & Interfaces,

Doi: https://doi.org/10.1021/am505682x

Supporting food effect prediction using biorelevant small scale in vitrosolubility approaches

Authors: Maria Inês Silvaa*, Qamar Abuhassana, Kate Pypera, Ibrahim Khadraa, Gavin Halbert2023

Journal: British Journal of Pharmacy

Doi: https://doi.org/10.5920/bjpharm.1411

Protein-based drug delivery nanomedicine platforms: recent developments.

Authors: Alaa A A Aljabali 1, Meriem Rezigue 1, Rawan H Alsharedeh 1, Mohammad A Obeid 1, Vijay Mishra 2, Ángel Serrano-Aroca 3, Murtaza M Tambuwala 42022

Journal: Pharmaceutical Nanotechnology

Doi: 10.2174/2211738510666220817120307

Protein-based Nanomaterials: a New Tool for Targeted Drug Delivery

Authors: Alaa AA AljabaliORCID Icon,Meriem Rezigue,Rawan H Alsharedeh,Mohammad A ObeidORCID Icon,Vijay MishraORCID Icon,Ángel Serrano-ArocaORCID Icon,Mohamed El-Tanani &Murtaza M Tambuwala2022

Journal: Therapeutic Delivery

Doi: https://doi.org/10.4155/tde-2021-0091

Structured solubility behaviour in bioequivalent fasted simulated intestinal fluids

Authors: Qamar Abuhassan a , Ibrahim Khadra a , Kate Pyper b , Patrick Augustijns c , Joachim Brouwers c , Gavin W. Halbert a2022

Journal: European Journal of Pharmaceutics and Biopharmaceutics

Doi: https://doi.org/10.1016/j.ejpb.2022.05.010

Synthesis, characterization, and assessment of anti-cancer potential of ZnO nanoparticles in an in vitro model of breast cancer.

Authors: Alaa A. A. Aljabali 1,*ORCID,Mohammad A. Obeid 1,Hamid A. Bakshi 2ORCID,Walhan Alshaer 3ORCID,Raed M. Ennab 4ORCID,Bahaa Al-Trad 5ORCID,Wesam Al Khateeb 5ORCID,Khalid M. Al-Batayneh 5ORCID,Abdulfattah Al-Kadash 6ORCID,Shrouq Alsotari 3,Hamdi Nsairat 7ORCI2022

Journal: Molecules

Doi: https://doi.org/10.3390/molecules27061827

Carbon-Based Nanomaterials: Promising Antiviral Agents to Combat COVID-19 in the Microbial-Resistant Era

Authors: Ángel Serrano-Aroca, Kazuo Takayama, Alberto Tuñón-Molina, Murat Seyran, Sk Sarif Hassan, Pabitra Pal Choudhury, Vladimir N Uversky, Kenneth Lundstrom, Parise Adadi, Giorgio Palù, Alaa A. A. Aljabali, Gaurav Chauhan, Ramesh Kandimalla, Murtaza M Tambuwala2021

Journal: ACS Nano

Doi: https://doi.org/10.1021/acsnano.1c00629

Fasted intestinal solubility limits and distributions applied to the biopharmaceutics and developability classification systems

Authors: Qamar Abuhassan a , Ibrahim Khadra a , Kate Pyper b , Patrick Augustijns c , Joachim Brouwers c , Gavin W. Halbert a2021

Journal: European Journal of Pharmaceutics and Biopharmaceutics

Doi: https://doi.org/10.1016/j.ejpb.2021.12.006

Small scale in vitro method to determine a bioequivalent equilibrium solubility range for fasted human intestinal fluid

Authors: Qamar Abuhassan a , Ibrahim Khadra a , Kate Pyper b , Gavin W. Halbert2021

Journal: European Journal of Pharmaceutics and Biopharmaceutics

Doi: https://doi.org/10.1016/j.ejpb.2021.08.002

Examination of the effect of niosome preparation methods in encapsulating model antigens on the vesicle characteristics and their ability to induce immune responses.

Authors: Mohammad A. ObeidORCID Icon,Teeranun Teeravatcharoenchai,David Connell,Kanidta Niwasabutra,Muattaz Hussain,Katharine Carter &Valerie A. Ferro2020

Journal: Journal of Liposome Research

Doi: https://doi.org/10.1080/08982104.2020.1768110

Preparation, characterization and antimicrobial assessment of selected ciprofloxacin salts

Authors: Hamdan, Imad I. , El-Sabawi, Dina , Darwish, Rula and Dahabiyeh, Lina A. 2020

Journal: Sciendo

Doi: https://doi.org/10.2478/acph-2021-0028

Covalent assembly of nanoparticles as a peptidase-degradable platform for molecular MRI

Authors: Francisco Perez-Balderas, Sander I. van Kasteren, Alaa A. A. Aljabali, Andrew Jefferson, Sébastien Serres, Manuel Sarmiento Soto, Alexandre A. Khrapitchev, James R. Larkin, Claire Bristow, Seung Seo Lee, Guillaume Bort, Filippo De Simone, Robin P. Choudhu2017

Journal: Nature Communications

Doi: https://doi.org/10.1038/ncomms14254

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