​ Efficient utilization of the limited Water, Energy, and Food (WEF) resources in stressed transboundary river ba sins requires understanding their interlinkages in different transboundary cooperation conditions. The Blue Nile Basin, a transboundary river basin between Ethiopia and Sudan, is used to illustrate the impacts of cooperation between riparian countries on the Water-Energy-Food nexus (WEF nexus). These impacts are quantified and evaluatedusingadailymodelthatsimulateshydrologicalprocesses,irrigationwaterrequirements,andwateral location to hydro-energy generation and irrigation water supply. Satellite-based rainfall data are evaluated and applied as a boundary condition to model the hydrological processes. Themodelisusedtodeterminechangesin the long-termeconomicgain (i.e. after infrastructure development plans are implemented and in steady operation) for each of Sudan and Ethiopia independently, and for the Blue Nile Basin from WEFin 120scenarios. Those scenarios result from combinations of three cooperation states: unilateral action, coordination, andcollaboration; and infrastructure developmentsettings including the GrandEthiopianRenaissance Damandplanned irrigation schemes in Sudan. The results show that the economic gain of the Blue Nile Basin from WEF increases with raising the cooperation level between Ethiopia and Sudan to collaboration. However, the eco nomic gain of each riparian country does not necessarily follow the same pattern as the economic gain of the basin​.