​This research aims to develop ethno socioscientific issues (ESsI) e-learning to empower students' creative thinking abilities. The design-based research (DBR) method consists of 4 steps, namely, analysis of e-learning needs, design planning, development, and reflection on results. The research subjects were high school students in the experimental group and control group. Collect pre-test and posttest data on creative thinking abilities, teacher and student response questionnaires. The data analysis technique uses the prerequisite tests for normality, homogeneity, and t-test hypothesis testing. The research results show that the development of ESsI e-learning meets the criteria of being valid, practical, and effective in empowering creative thinking skills. The practicality of ESsI e-learning through student and teacher responses is in a good category, meaning it is easy to use the product developed. Based on the t-test, there are differences in the results of the creative thinking skills of experimental and control group students. The effectiveness of ESsI e-learning is because it can provide opportunities for scientific thinking in exploring scientific issues developing in society in the reconstruction of materials. The impact of research in the form of innovative ESsI e-learning can provide opportunities for students to think creatively, making learning meaningful without abandoning culture.​​